Serotonin actions within the prelimbic cortex induce anxiolysis mediated by serotonin 1a receptors
نویسندگان
چکیده
منابع مشابه
Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.
Selective serotonin reuptake inhibitors are the mostly widely used treatment for major depressive disorders and also are prescribed for several anxiety disorders. However, similar to most antidepressants, selective serotonin reuptake inhibitors suffer from two major problems: They only show beneficial effects after 2 to 4 weeks and only about 33% of patients show remission to first-line treatme...
متن کاملSerotonin, serotonin receptors and their actions in insects
Serotonin is an ancient monoamine neurotransmitter, biochemically derived from tryptophan. It is most abundant in the gastrointestinal tract, but is also present throughout the rest of the body of animals and can even be found in plants and fungi. Serotonin is especially famous for its contributions to feelings of well-being and happiness. More specifically it is involved in learning and memory...
متن کاملModulation of anxiety by cortical serotonin 1A receptors
Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals. Mice lacking Htr1a show increased anxiety behavior suggesting that its activation by serotonin has an anxiolytic effect. This outcome can be mediated b...
متن کاملSerotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice
Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be def...
متن کاملSerotonin 1A receptors alter expression of movement representations.
Serotonin has a myriad of central functions involving mood, appetite, sleep, and memory and while its release within the spinal cord is particularly important for generating movement, the corresponding role on cortical movement representations (motor maps) is unknown. Using adult rats we determined that pharmacological depletion of serotonin (5-HT) via intracerebroventricular administration of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Psychopharmacology
سال: 2018
ISSN: 0269-8811,1461-7285
DOI: 10.1177/0269881118817384